Cyberattack suspect to be sent home to Netherlands

MADRID (AP) ? A Dutch citizen arrested in Spain on suspicion of launching what authorities have called the biggest cyberattack in Internet history is expected to be handed over to the Netherlands within 10 days, a Spanish court official said Monday.

The suspect ? identified only by his initials S.K. ? was questioned Saturday in the National Court in Madrid after his arrest last week and agreed to the deal, according to the official, who spoke on condition of anonymity because court rules prevent him from giving his name.

Police say the 35-year-old suspect operated from a bunker in northeast Spain and also had a van capable of hacking into networks anywhere in the country. He was arrested Thursday in Granollers, 35 kilometers (22 miles) north of Barcelona.

He is accused of attacking the anti-spam watchdog group Spamhaus, whose main task is to halt ads for counterfeit Viagra and bogus weight-loss pills reaching the world's inboxes.

Dutch authorities alerted Spanish police in March of large denial-of-service attacks being launched from Spain that were affecting Internet servers in the Netherlands, United Kingdom and the U.S. These attacks culminated with a major onslaught on Spamhaus.

Denial-of-service attacks overwhelm a server with traffic, jamming it with incoming messages. Recent cyberattacks ? such as the ones that caused outages at U.S. banking sites last year ? have tended to peak at 100 billion bits per second. The attack on Spamhaus was three times that size.

Police from the Netherlands, Germany, Britain, Spain and the U.S. took part in the investigation.

Source: http://news.yahoo.com/cyberattack-suspect-sent-home-netherlands-123458203.html

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Celtics hoping revived offense has life in Game 5

BOSTON (AP) ? It started with a 3-pointer by Avery Bradley 16 seconds into the game. It ended with a layup by Jason Terry with 6.5 seconds left.

Yes, the Boston Celtics finally got their offense going.

"It's coming," Terry said. "You can feel it."

It was there on Sunday ? for much of the game, anyway ? when the Celtics beat the New York Knicks 97-90 in overtime to avoid being swept in the opening round of the playoffs.

But if it's not there on Wednesday night in New York, the Celtics will have a very tough time forcing a sixth game Friday night in Boston.

The Celtics scored fewer than 20 points in six of the first 10 quarters in the series. They managed a meager eight points in the fourth quarter of the opener ? one less than Terry scored by himself in the last 1:32 of overtime on Sunday. They scored 78, 71 and 76 points in the first three games after scoring fewer than 80 just five times during the regular season.

"We've got a lot of basketball in us," Terry said, "but there's always something like one quarter that holds us back. So if we can put together four quarters of great Celtics basketball, ball movement, getting out in transition, then this series is going to be a long one."

The Celtics made 51.3 percent of their shots in the first half Sunday after averaging 39.5 during the first three games. But they dropped to 25 percent (4 for 16) in the third quarter when the Knicks cut a 59-39 deficit to 68-65 entering the fourth.

And they finished with just three offensive rebounds ? and only two second-chance points ? in 53 minutes. The Knicks got five offensive rebounds from Tyson Chandler and four from Iman Shumpert.

But Boston managed to win when New York's own shooting woes continued in overtime with only two field goals in eight attempts. Carmelo Anthony hit just one of four shots in overtime and finished at 10 for 25, despite leading all scorers with 36 points.

"We didn't shoot the ball well," Anthony said, "and we still put ourselves in a position to win the basketball game. There's an upside to that."

The downside for him was the Celtics' defense, particularly that of Brandon Bass. Before fouling out with 4:27 left in the fourth quarter, he guarded Anthony tightly, contested shots and kept the NBA's leading playoff scorer from getting hot. Anthony missed all seven of his 3-pointers and got 16 of his 36 points on free throws.

Boston coach Doc Rivers praised Bass' performance.

"He was the star of the game," Rivers said. "He just defended and did it over and over and over again."

The Knicks got back in the game after Anthony picked up his fourth foul with New York trailing 65-51 with 3:35 left in the third quarter. With Anthony on the bench, Raymond Felton scored 11 points in a 14-3 run that cut the deficit to 68-65.

"The fact that we came back from a 20-point deficit in that building shows a lot about our team," Felton said.

When they get to their own building, they'll have their second leading scorer back. J.R. Smith, the NBA's Sixth Man of the Year, was suspended for Sunday's game for hitting Terry with an elbow in New York's 90-76 win in Game 3. Smith is averaging 16.3 points per game in the series.

Felton helped take up the slack with 27 points, but Smith's perimeter shooting will put more pressure on the Celtics' defense and, perhaps, open up the lane for the Knicks' offense.

"You just don't know what the impact was" of Smith's absence, Rivers said, "but guarding one less guy can't hurt."

Smith's return may be too much for the Celtics, especially after their best players put in a very long day with 35-year-old Paul Pierce playing 49 minutes, 51 seconds and 36-year-old Kevin Garnett going 36:57. They're hoping that two days between games will be enough time for them to recover.

But the Celtics need a lot more than their veteran stars. Terry proved that on Sunday.

"He's got to be our X-factor," Pierce said. "Guys are going to load up to me, load up to Kevin, and he's got to be our X-factor and we depend on him for that."

On Sunday, the Celtics played beneath 17 NBA championship banners hanging from the rafters. Before the game, the video board above the court showed past Celtics greats ? Bob Cousy, Bill Russell, John Havlicek, Larry Bird and others.

Getting swept would have tarnished that tradition.

"There's just so much pride when you look around," Pierce said, "the banners, the crowd and everything going on with the Boston Celtics history."

That will be missing in Madison Square Garden on Wednesday night.

Just one more victory and the Knicks will celebrate their first playoff series win since 2000, when they reached the Eastern Conference finals. And no NBA team has ever won a series after losing the first three games.

"We played all year to get homecourt advantage and if you get one (win) on the road, that's a major plus," Knicks coach Mike Woodson said. "We just have to go home and handle our business."

Source: http://news.yahoo.com/celtics-hoping-revived-offense-life-game-5-202628630.html

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Smoking gun in West, Texas, fertilizer blast: lack of government oversight

While the cause of the blast in West, Texas, is still undetermined, what is clear is that the West Fertilizer Company stored large quantities of reactive products in the middle of a small town with little state or federal oversight. Citizens must be empowered to act when regulators don't.

By Thomas O. McGarity / April 29, 2013

Mike Maler, right, comforts neighbor Lori Eisma when he visits her house in West, Texas, April 27. Mr. Maler's home was also destroyed by the West Fertilizer Company explosion on April 17. Op-ed contributor Thomas O. McGarity writes: 'Given the reluctance of Congress to properly fund the regulatory agencies, it may be time to give workers and neighbors the tools' to hold companies accountable.

Kye R. Lee/The Dallas Morning News/AP

Enlarge

The tragic explosion at a West, Texas, fertilizer plant April 17 is the most recent manifestation of a badly debilitated system of regulatory protections.

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Although the cause of the blast is still undetermined, what is clear is that the West Fertilizer Company stored large quantities of highly reactive products, including anhydrous ammonia and ammonium nitrate, in the middle of a small town with very little oversight from state or federal agencies. Ammonium nitrate was used by the Oklahoma City bomber Timothy McVeigh in 1995, killing 168 people. The West, Texas, explosion killed 14, and injured nearly 200.

Texas does not have an occupational safety and health program that meets federal requirements. The federal Occupational Safety and Health Administration (OSHA) is therefore responsible for ensuring the safety of potentially dangerous workplaces like the West facility.

OSHA has inspected the West plant exactly once in the company?s 51-year history. That 1985 inspection detected multiple ?serious? violations of federal safety requirements for which the company paid a grand total of $30 in fines. OSHA?s 1992 process-safety-management standard for highly hazardous chemicals is supposed to protect against disasters like the West explosion, but it wasn?t in place for that inspection.

Regardless, OSHA lacks the resources to undertake the kind of comprehensive inspection needed to ensure compliance with the process safety standard at small facilities like West Fertilizer Company. OSHA?s tiny staff of around 2,400 inspectors is spread so thin that it would take more than 90 years to conduct even cursory inspections of all eligible workplaces in Texas.

The Environmental Protection Agency (EPA) inspected the facility in 2006 and assessed a fine of $2,300 for failing to update a risk management plan, among other violations involving employee training records and maintenance. The company responded in 2011 with an updated plan stating that the ?worst case release scenario? was a release of the contents of a storage tank over a period of 10 minutes; the threat of an explosion was not mentioned. The EPA? was apparently satisfied. The EPA lacks the staff to inspect any given facility more than once every decade or so.

The Texas Commission on Environmental Quality has so few inspectors that it can only inspect small plants like the West facility in response to complaints. It inspected the West plant in 2006 in response to a complaint about bad odors, and it was satisfied when the company applied for a new permit. Inspectors weren?t focused on the risk of explosion, though the US Pipeline and Hazardous Materials Safety Administration did fine the company $5,250 that year for improperly planning to transport anhydrous ammonia.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/74NWg5Cftog/Smoking-gun-in-West-Texas-fertilizer-blast-lack-of-government-oversight

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Day Two Of TechCrunch Disrupt NY 2013: Watch The Live Stream Here

It’s day two here at?TechCrunch Disrupt NY 2013, and we’ve got another full day of fireside chats, founders’ stories and startup battlefield pitches for your viewing pleasure. As with yesterday, we?ll be live streaming all the action — expect the live stream to kick off around 8:45am ET and end about 6pm when the last battlefield pitch concludes. One note: we’re not live streaming the exclusive screening of Downloaded. Only Disrupt attendees get to enjoy that. But for everything else, follow along on the live stream and tweet with us at #TCdisrupt. Coming up in the morning we’ve got fireside chats with the likes of Mailbox’s Gentry Underwood, now a part of Dropbox?so that should be an interesting conversation, and eBay’s John Donahoe, along with panels on digital advertising (with speakers from Google, Facebook and Twitter) and digital money (with Stripe, PayPal and Gumroad). Moving into the afternoon highlights include?Shawn Fanning?and?Alex Winter?talking about their film?Downloaded. And of course, the next round of the startup battlefield. Here’s the full agenda for the day: 9:00am ? 9:05am Opening Remarks by TechCrunch 9:05am ? 9:35am Fireside Chat with?Fred Wilson?(Union Square Ventures) 9:35am ? 10:00am Founders Stories with?Gentry Underwood?(Mailbox) 10:00am ? 10:25am Ads: Your Eyeballs Are Money:?Neal Mohan?(Google),?Gokul Rajaram?(Facebook),?Kevin Weil(Twitter) 10:25am ? 10:50am Fireside Chat with?John Donahoe?(ebay) 10:50am ? 11:00am Special Product Announcement 11:00am ? 11:20am BREAK 11:20am ? 11:45am Lots of Venture, But What is Gained?:?Mike Abbott?(Kleiner Perkins Caufield & Byers),?Aaref Hilaly(Sequoia Capital),?Naval Ravikant?(Angel List),?David Tisch?(Box Group) 11:45am ? 12:05pm In Conversation with?Troy Carter?(Atom Factory) 12:05pm ? 12:30pm Show Me the [Digital] Money:?John Collison?(Stripe),?Hill Ferguson?(PayPal),?Sahil Lavinga(Gumroad) 12:30pm ? 2:00pm LUNCH 2:00pm ? 2:25pm Downloaded with?Shawn Fanning?(Airtime) and?Alex Winter?(filmmaker) Startup Battlefield with?Jason Kincaid 2:25pm ? 2:30pm How the Startup Battlefield Works 2:30pm ? 3:30pm Session Four ? Layers of Experience Judges:?Heidi Messer?(Collective[i]),?Peter Pham?(Science),?Dave Samuel?(Freestyle Capital),?Scott Stanford?(Sherpa Foundry) 3:30pm ? 3:45pm BREAK 3:45pm ? 4:45pm Session Five ? New Marketplaces Judges:?Pat Gallagher?(CrunchFund),?Zach Sims?(Codecademy),?David Tisch?(Box Group),Michelle Zatlyn?(CloudFlare) 4:45pm ? 5:00pm BREAK 5:00pm ? 6:00pm Session Six ? Mobile First Judges:?Matt Brezina?(Sincerely),?Nicole Glaros?(Techstars),?Naval Ravikant?(Angel List),?Lior Zorea?(Perkins Coie) 6:15pm ? 8:15pm Downloaded?? Exclusive Screening at TechCrunch Disrupt in advance of the digital and theatrical release later this year. 9:00pm ? Midnight After Party hosted by?MailWeGo?at?Hudson Terrace

Source: http://feedproxy.google.com/~r/Techcrunch/~3/8LnsxDuQLhI/

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LG unveils Optimus GK in Korea, brings G Pro features in a 5-inch package

Not tired of seeing different versions of the Optimus G? LG has just revealed another variant for Korean customers: the Optimus GK. Similar to the one-off Optimus G Pro it delivered in Japan on NTT DoCoMo, this handset has features pinched from the 5.5-inch Pro (1.7GHz Snapdragon 600 CPU, 2GB RAM) squeezed into a more-pocketable 5-inch frame. The 1080p screen here (440PPI) is Full HD IPS like the one we're expecting to see in AT&T's Optimus G Pro in a few days, matched a 3,100mAh battery, 16GB of storage, microSD slot and 13MP/2MP rear/front camera setup. This particular variant had been rumored to launch at MWC but is only now being announced for Korean carrier KT, we'll see how many more twists LG can wring out of the Optimus G platform before delivering a true sequel later this year.

Filed under: Cellphones, Mobile, LG

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Source: LG Korea

Source: http://www.engadget.com/2013/04/28/lg-optimus-gk-5-inch-kt/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Turtle genome analysis sheds light on turtle ancestry and shell evolution

Apr. 28, 2013 ? From which ancestors have turtles evolved? How did they get their shell? New data provided by the Joint International Turtle Genome Consortium, led by researchers from RIKEN in Japan, BGI in China, and the Wellcome Trust Sanger Institute in the UK provides evidence that turtles are not primitive reptiles but belong to a sister group of birds and crocodiles. The work also sheds light on the evolution of the turtle's intriguing morphology and reveals that the turtle's shell evolved by recruiting genetic information encoding for the limbs.

Turtles are often described as evolutionary monsters, with a unique body plan and a shell that is considered to be one of the most intriguing structures in the animal kingdom.

"Turtles are interesting because they offer an exceptional case to understand the big evolutionary changes that occurred in vertebrate history," explains Dr. Naoki Irie, from the RIKEN Center for Developmental Biology, who led the study.

Using next-generation DNA sequencers, the researchers from 9 international institutions have decoded the genome of the green sea turtle and Chinese soft-shell turtle and studied the expression of genetic information in the developing turtle.

Their results published in Nature Genetics show that turtles are not primitive reptiles as previously thought, but are related to the group comprising birds and crocodilians, which also includes extinct dinosaurs. Based on genomic information, the researchers predict that turtles must have split from this group around 250 million years ago, during one of the largest extinction events ever to take place on this planet.

"We expect that this research will motivate further work to elucidate the possible causal connection between these events," says Dr. Irie.

The study also reveals that despite their unique anatomy, turtles follow the basic embryonic pattern during development. Rather than developing directly into a turtle-specific body shape with a shell, they first establish the vertebrates' basic body plan and then enter a turtle-specific development phase. During this late specialization phase, the group found traces of limb-related gene expression in the embryonic shell, which indicates that the turtle shell evolved by recruiting part of the genetic program used for the limbs.

"The work not only provides insight into how turtles evolved, but also gives hints as to how the vertebrate developmental programs can be changed to produce major evolutionary novelties." explains Dr. Irie.

Another unexpected finding of the study was that turtles possess a large number of olfactory receptors and must therefore have the ability to smell a wide variety of substances. The researchers identified more than 1000 olfactory receptors in the soft-shell turtle, which is one of the largest numbers ever to be found in a non-mammalian vertebrate.

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The above story is reprinted from materials provided by RIKEN, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa, Wenqi Li, Yoshihito Niimura, Zhiyong Huang, Chunyi Li, Simon White, Zhiqiang Xiong, Dongming Fang, Bo Wang, Yao Ming, Yan Chen, Yuan Zheng, Shigehiro Kuraku, Miguel Pignatelli, Javier Herrero, Kathryn Beal, Masafumi Nozawa, Qiye Li, Juan Wang, Hongyan Zhang, Lili Yu, Shuji Shigenobu, Junyi Wang, Jiannan Liu, Paul Flicek, Steve Searle, Jun Wang, Shigeru Kuratani, Ye Yin, Bronwen Aken, Guojie Zhang, Naoki Irie. The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics, 2013; DOI: 10.1038/ng.2615

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/8zHOVHrvis0/130428144848.htm

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Two police officers shot as Italian government sworn in

By Gavin Jones and Roberto Landucci

ROME (Reuters) - Two Italian police officers were shot and wounded on Sunday outside the prime minister's office in Rome just as new premier Enrico Letta's government was being sworn in just a kilometer (mile) away.

It was not clear whether the attack by a man police said was unemployed was linked to the launch of the new government at a time of deep political divisions and social tensions exacerbated by a long slump in the euro zone's third largest economy.

Newly installed Interior Minister Angelino Alfano said the attack appeared to be an "isolated act" that did not suggest any wider security threat. But there were immediate calls for politicians to try to calm a volatile public mood.

"All political forces have to work together to lower the level of tension that the economic, social and institutional climate has already created," said center-left parliamentarian Emanuele Fiano.

Letta, 46, the moderate deputy head of the center-left Democratic Party (PD), on Saturday ended two months of political stalemate after February's inconclusive election when he united former political rivals in a broad coalition government.

The mix of center-right and center-left politicians and unaffiliated technocrats was largely welcomed in Italy's mainstream press on Sunday, especially for the record of seven female ministers and the relatively young average age.

However, the political risks that Letta faces were spelled out on Sunday by a close ally of center-right leader Silvio Berlusconi who is a core stakeholder in the government.

Renato Brunetta, lower house leader of Berlusconi's People of Freedom party (PDL), said the government would fall unless Letta promised in his maiden speech to swiftly abolish an unpopular housing tax and repay the 2012 levy to taxpayers.

Letta is expected to set out his government's plans in parliament on Monday and will then need to win a vote of confidence in both houses to be fully empowered.

"If the prime minister doesn't make this precise commitment we will not give him our support in the vote of confidence," Brunetta told daily Il Messaggero.

Brunetta, who was himself a candidate for the post of economy minister, said that during negotiations for the formation of the government Letta had "given his word" on the abolition and repayment of the tax, which would leave an 8-billion-euro hole in public accounts.

New Economy Minister Fabrizio Saccomanni, formerly deputy governor of Italy's central bank, said he wanted to cut public spending and reduce taxes to revive an economy languishing in a recession set to be the longest since World War Two.

He made no reference to the housing tax. Attention on Sunday, however was focused on the dramatic shooting outside Palazzo Chigi, the prime minister's official residence.

"SHOOT ME"

Police identified the gunman as Luigi Preiti, in his forties, from Calabria, the southern region which has long suffered from high unemployment and organized crime.

Having fired several shots at the two police on duty outside the prime minister's office, he shouted "shoot me, shoot me" to other police officers nearby, police said.

One of the two officers was shot in the neck and was in a serious though not life-threatening condition, while the other was shot in the leg and less seriously hurt.

In a surreal scene, outgoing Prime Minister Mario Monti received the official trumpet salute in the courtyard of the renaissance Chigi palace before walking across the cordoned-off square past police crouching over the scene of the shooting.

Preiti was unemployed and separated from his wife, but had never suffered from mental illness, his brother told Italian news agency ANSA.

In the election Italians vented their anger at a discredited political class by giving 25 percent of votes to the anti-establishment 5-Star Movement led by former Comic Beppe Grillo.

Since the vote, divisions have deepened with millions of center-left voters furious to see the PD split and then agree to govern with arch-enemy Berlusconi after its leadership, including Letta, had repeatedly ruled out the possibility.

PD parliamentarians have been subjected to abuse in the streets and Grillo rubs salt in the party's wounds with daily comments on his blog decrying what he sees as an indecent alliance to preserve the power and privileges of the status quo.

Berlusconi, who had been widely written off after being forced from office in 2011 at the height of a debt crisis, has emerged as the big winner. He is now a vital part of the ruling majority and has placed several ministers in the cabinet, including the PDL's national secretary Alfano as deputy prime minister and interior minister.

Recent polls give him a lead of between five and eight percentage points over the center-left, and many commentators believe he may bring down the government as soon as he is fully confident of winning an election.

(Reporting by Gavin Jones, James Mackenzi, Antonella Cinelli, Roberto Landucci; Editing by James Mackenzie and Mark Heinrich)

Source: http://news.yahoo.com/italian-government-under-enrico-letta-sworn-094720376.html

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Mapping of cancer cell fuel pumps paves the way for new drugs

Public release date: 28-Apr-2013
[ | E-mail | Share ]

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says Pr Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

###

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

Publication: 'Structural basis for substrate transport in the GLUT homology family of monosaccharide transporters', Esben M. Quistgaard, Christian Lw, Per Moberg, Lionel Trsaugues, and Pr Nordlund, Nature Structural & Molecular Biology, online 28 April 2013, doi: 10.1038/nsmb.2569. EMBARGOED until Sunday 28 April 2013 at 18:00 UK time / 19:00 CET / 13:00 US ET.

Journal website: http://www.nature.com/nsmb

Contact the Press Office: ki.se/pressroom

Karolinska Institutet a medical university: ki.se/english

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 28-Apr-2013
[ | E-mail | Share ]

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. Since tumours are highly dependent on the transportation of nutrients in order to be able to grow rapidly, the researchers are hoping that the study published in the scientific magazine Nature Structural & Molecular Biology will form the basis for new strategies to fight cancer cells.

In order to be able to fuel their rapid growth, cancer tumours depend on transporter proteins to work at high speed to introduce sugars and other nutrients that are required for the cell's metabolism. One possible treatment strategy would therefore be to block some of the transporters in the cell membrane which operate as fuel pumps, thus starving out and killing the cancer cells.

One important group of membrane transporters is the GLUT family, which introduces glucose and other sugars into the cell. Glucose is one of the most important energy sources for cancer cells and GLUT transporters have been shown to play a key role in tumour growth in many different types of cancer. In the current study, researchers from Karolinska Institutet have performed a detailed study of the way in which suger transport is executed by the protein XylE, from the Escherichia coli bacterium, whose function and structure is very similar to GLUT transporters in humans. For the first time, the researchers have described the way in which the protein's structure changes between two different conformations when it binds and transports a sugar molecule.

"In showing details of the molecular structure of the region that bind the sugar, our study opens up the opportunities to more efficiently develop new substances that may inhibit GLUT transporters", says Pr Nordlund at the Department of Medical Biochemistry and Biophysics, one of the researchers behind the study. "Information on the structure of the transport protein facilitates the development of better drugs in a shorter time. Such GLUT inhibitors could potentially be used to treat cancer in the future."

The study may be of significance not just to cancer research but also in the field of diabetes. GLUT plays a key role in diabetes since insulin works by activating the uptake of glucose from the blood by means of GLUT transporters in the cell membrane.

GLUT and the studied XylE transporter belong to the very large group of metabolite transporters called the Major Facilitator Superfamily (MFS), which is important in many diseases and for the uptake of medicines in cells.

"Many aspects concerning molecular mechanisms for the function of GLUT transporters are probably common to many members of the MFS family, which are involved in a broad spectrum of diseases in addition to cancer and diabetes," says Pr Nordlund.

As well as membrane transporters, which have undergone in-depth analysis in the current study, many different membrane proteins pass through the surface membrane of the cells. Their significance to the cell function and the development of drugs has been noted before, not least through the Nobel Prizes that were awarded to researchers who used mechanistic and structural studies to map the function of two other major membrane protein families, G-protein-coupled receptors and ion channels.

###

The current study has been financed by grants from the Swedish Research Council, the Swedish Cancer Society, the European Molecular Biology Organization (EMBO) and The Danish Council for Independent Research.

Publication: 'Structural basis for substrate transport in the GLUT homology family of monosaccharide transporters', Esben M. Quistgaard, Christian Lw, Per Moberg, Lionel Trsaugues, and Pr Nordlund, Nature Structural & Molecular Biology, online 28 April 2013, doi: 10.1038/nsmb.2569. EMBARGOED until Sunday 28 April 2013 at 18:00 UK time / 19:00 CET / 13:00 US ET.

Journal website: http://www.nature.com/nsmb

Contact the Press Office: ki.se/pressroom

Karolinska Institutet a medical university: ki.se/english

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/ki-moc042613.php

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Surprising Lunar Eclipse Wows Skywatchers (Photos)

The moon toe-dipped through the Earth's shadow in a partial lunar eclipse Thursday (April 25), but stargazers around the world still captured surprisingly spectacular views of what they expected to be a minor celestial event.

Partial lunar eclipses like Thursday's event occasionally receive a bad wrap because they aren't nearly as dramatic as the red glow of the moon during a total lunar eclipse, and some times they aren't even noticeable. That, however, wasn't the case today.

A live webcast from a telescope in Dubai and hosted by the online Slooh Space Camera streamed amazing views of the lunar eclipse at its peak around 4 p.m. EDT (2000 GMT). The lunar eclipse's entirety was primarily visible from Africa, Eastern Europe, Central Asia and Western Europe, so stargazers in other parts of the world had to rely on webcasts like those provided by Slooh and the Virtual Telescope Project in Italy to catch the event. [See more photos of Thursday's Lunar Eclipse]

"I am still stunned," Slooh President Paul Cox said during his group's webcast. "I thought we were going to have trouble discerning any shadow at all from this lunar eclipse."

Instead Cox and his fellow co-hosts were met with gorgeous shots of the Earth's shadow passing over the face of the moon. During the eclipse, a small upper left-hand section of the full moon was totally obscured, a beautiful and unexpected sight.

"It's only more recently that I've become a fan of lunar eclipses because they're beautiful in their own right," solar scientist Lucie Green of the Mullard Space Science Laboratory in the United Kingdom said during the Slooh webcast.

This particular lunar eclipse defied expectation partially because the satellite only passed through a small portion of the umbra of the Earth ? the innermost shadow of the planet that prevents any direct sunlight from reaching the moon.

A total lunar eclipse occurs when?the moon passes directly within this inner shadow, but those are rare. The moon is slightly tilted in its orbit around the Earth, preventing it from orbiting on the same plane as the planet. If it did, we would have a total lunar and a total solar eclipse every month.

"Amazing view, the moon, even with such small eclipses, it always breathtaking," astrophysicist Gianluca Masi, who hosted the Virtual Telescope Project webcast today, told SPACE.com in an email.

Typically, ?partial lunar eclipses can be difficult to see at all, but Thursday's event not only impressed lunar observers, but also photographers hoping to catch a glimpse of the moon and another celestial body.

"Like every year we capture this events," photographer Stojan Stojanovski said of the eclipse. "I may say this year is special because we have Saturn near moon at the same time with eclipse. This night will be long first because we take photos from eclipse, second level will be watching and taking some photos of Saturn."

Saturn will appear near the moon?tonight. If you hold your closed fist at an arm's length toward the night's sky, the ringed wonder should be less than "half a fist" way from the moon.

If weather permits, the planet will look like a bright star to the upper-left of the moon and should appear all night long. The planet is close to a point in the night sky called "opposition," when it will be directly opposite the sun.

Saturn's opposition will be the next broadcast from Slooh carried on SPACE.com this Sunday (April 28) during its peak.

Editor's note: If you snap a great photo of the April 25 lunar eclipse or any other celestial event that you'd like to share for a possible story or image gallery, send photos, comments and your name and location to managing editor Tariq Malik at spacephotos@space.com.

Follow Miriam Kramer Twitter?and Google+. Follow us @Spacedotcom, Facebookand Google+. Original article on SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/surprising-lunar-eclipse-wows-skywatchers-photos-225236206.html

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On immigration, it?s pathway to citizenship or bust

Sens. John McCain and Chuck Schumer (Christian Science Monitor)

The lead authors of the Senate immigration reform bill are dug in on the question of whether the final product must include a "pathway to citizenship" for many of the 11 million immigrants living in the U.S. illegally.

The bill will die if it does not include such a pathway, Republican Sen. John McCain of Arizona and Democratic Sen. Chuck Schumer of New York told reporters Thursday.

"There's no way of getting this job done without giving people a path to citizenship," McCain said during a Christian Science Monitor breakfast that Schumer also attended. "To say that you can have a legal status but you can't ever have a path to become a citizen of his country offends our fundamental principles of fairness in this country. I know that that opposition is there; I don't think it's valid and I don't think it's held even by a majority of Republicans, certainly not in the Senate."

Whether unauthorized immigrants should be given the choice to remain here without returning to their home country first has remained a sticking point for some Republicans lawmakers. In an interview with CBS News on Wednesday, Texas Republican Sen. Ted Cruz warned that including a pathway to citizenship would likely "scuttle the bill." Others in the House have said they will refuse any attempts to offer what they call "amnesty" for such immigrants.

According to the language of the Senate bill, those living in the U.S. illegally who arrived before Dec. 31, 2011 must wait up to 13 years to achieve citizenship, and only after undergoing a rigorous application system that includes background checks, proof of access to gainful employment and the paying of back taxes and fines. The federal government will also have to comply with a strict set of enforcement mandates for the pathway provisions to trigger.

During the breakfast meeting, Schumer seconded McCain's prediction about the bill's fate.

"Any attempt to say in the House that you will not have a path to citizenship will be a non-starter, and I say that unequivocally," Schumer said, pounding his fist on the table. "It will not pass the Senate. I don't think it would get a Democratic vote."

"A majority of Republicans support it," Schumer said, before McCain interjected.

"As long as?" McCain said.

"?there's a path," Schumer said. "You earn it."

"Right," McCain added.

McCain also reiterated his warning to Republicans that a failure to pass an immigration overhaul could be devastating to the party in the future. Passage won't automatically gain votes, he said, but it will keep the party competitive.

"If we pass this legislation, it won't gain us a single Hispanic vote. But what it will do is put us on a playing field where we can compete. Right now we cannot compete," McCain said. "It's a demographic certainty that if we condemn ourselves to 15, 20, 25 percent of the Hispanic vote, we will not win elections, but I have no illusions about whether passage of this legislation will gain Hispanic voters. It won't."

The Senate is currently holding hearings about the immigration bill in the Judiciary Committee and supporters say they expect a vote in the chamber by early summer.

Source: http://news.yahoo.com/blogs/ticket/immigration-bill-authors-pathway-citizenship-bust-151543776--politics.html

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Gwyneth Paltrow named People's most beautiful woman

(Ends first round) NEW YORK, April 25 (Reuters) - Selections in the first roundof the 2013 NFL Draft at Radio City Music Hall on Thursday (picknumber, NFL team, player, position, college): 1-Kansas City, Eric Fisher, offensive tackle, Central Michigan 2-Jacksonville, Luke Joeckel, offensive tackle, Texas A&M 3-Miami (from Oakland), Dion Jordan, defensive tackle, Oregon 4-Philadelphia, Lane Johnson, offensive tackle, Oklahoma 5-Detroit, Ezekiel Ansah, defensive end, Brigham Young 6-Cleveland, Barkevious Mingo, linebacker, LSU 7-Arizona, Jonathan Cooper, guard, North Carolina 8-St. ...

Source: http://news.yahoo.com/gwyneth-paltrow-named-peoples-most-beautiful-woman-165921879.html

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Ore. department's concrete police pig back in pink

ASTORIA, Ore. (AP) ? The Astoria Police Department's concrete pig is back in the pink and ready for another 20 years of duty.

The Daily Astorian reports (http://bit.ly/ZPr4hW ) the pig was dropped off at the station in 1993 by someone who didn't stay to explain the gift.

Unoffended, the police promptly adopted the animal and left it in place.

But two decades took a toll, washing off the pink paint, pitting the surface, loosening the ears.

Michael Peden, the 16-year-old grandson of a department administrator, took on the restoration chores as an Eagle Scout project.

Now the department has stationed the restored pig in a more prominent location, as it said in a news release, "at the entrance to the Police Department parking area, watching the comings and goings of police officers."

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Information from: The Daily Astorian, http://www.dailyastorian.com

Source: http://news.yahoo.com/ore-departments-concrete-police-pig-back-pink-010228333.html

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The Best Experimental Chrome Features You Should Check Out

Google Chrome is a great browser as it is, but that doesn't mean it doesn't come with its share of annoyances and curiosities. You can fix some of these, as well as add new features by playing around with Chrome's experimental settings. Here are a few we really like.

When you type chrome://flags into your URL bar in Chrome, you get all kinds of crazy options for experimental features. Some of these can fix problems with Chrome, others do absolutely nothing, and others might wreak havoc on your system, so use them with caution. With that in mind, here are a few we've tested and love, although your mileage may vary.

Generate Passwords

If you're not using a password manager like LastPass (and you really should be) then you probably find yourself just reusing the same password over and over. That's no good for security, and while you're better off with a password manager, if you're holding out, you can generate new passwords right in Chrome. Just head to the Flags page, and enable, "Enable password generation." Now when you go to a new signup page, you'll see a small key icon. Click that, and Chrome will automatically make a password for you that's synced across all your versions of Chrome.

Tab Overview with a Gesture

Mac only: If you're a Mac user on a laptop you know the trials of having way too many tabs open. They line up across the top of the browser and suddenly you can't tell which tab is which. If you enable the experimental feature, "Tab Overview Mac," you can get a quick look at all the tabs you have open by holding down Option and swiping down with three fingers. It's incredibly handy.

Tab Stacking

Windows only: If you're on Windows and have a tab problem, Chrome has you covered there as well. When you enable "Tab Stacking" your tabs automatically start stacking on top of each other instead of just side-by-side when you have a ton open. As Ghacks points out, it's a feature that's been in Opera for a while. Tab stacking still needs a little work on Chrome, but it's better than nothing.

Speed Up Chrome's Performance

Whether Chrome is running slow or you simply want it to run faster, you have a few different options that can help boost performance. Enabling any of these can cause some problems with different video cards, so if you run into problems you might need to turn them off. Head into the flags page and enable these settings:

• GPU compositing on all pages: This option should speed up Chrome across the board by giving your GPU more stuff to do. We've had mixed luck with this one, so use at your own risk.
• Threaded compositing: As cool as the name sounds, you'll probably only get smoother scrolling when a page is loading with this enabled. Still, that's helpful enough for those slow-loading pages.
• GPU Accelerated SVG Filters: This might speed up graphics-heavy sites that have a lot of effects like shaders going on.

Those are the only ones that will speed up performance without significantly changing how web pages look. Other options, like "Disable accelerated 2D canvas," might speed up performance but it might have a negative effect on how pages are displayed.

Make Browsing On Touch Screen Computers Bearable

Chrome's not made for touch screen computers, and that means that browsing on something like a Microsoft Surface is next to impossible. Thankfully, our own Melanie Pinola tested out a few of the experimental features and recommends enabling the following flags: "Touch Optimized UI," "Enable Touch Events," and "Enable Touch Initiated Drag and Drop." Combined, those should make it possible to use Chrome on your Windows touch device without giving you a headache.

Keep an Eye On What Your Extensions Are Doing

Chrome extensions want access to all kinds of data, and if you're uncomfortable with that you might want to peek under the hood and see what they're doing. When you turn on "Enable extension activity UI" a new option is added to the Extensions tab in your Settings. When you click "Activity," Chrome starts logging what the extension is doing so you can get a look at it and make sure it's not doing anything you don't want. It's a little hard to read, but you can at least decipher a little bit of what it's up to.

Fix Annoyances

The other thing that Chrome's Flags do is fix common annoyances. Occasionally, Chrome adds a new feature that makes things work differently, or that starts shooting out annoying notifications. The first place to check is the flags to see if you can disable it, but here are a few that fix common annoyances:

• Revert to the Old "New Tab" Page: Just find "Enable Instant Extended API" and set it to "disabled." This should bring back the old "new tab" page with history and "recently closed" at the forefront.
• Turn Off Chrome Notification in Windows: If the way Chrome's notification icon sticks around after you close it is annoying you then turning it off is pretty simple. Just find "Enable Rich Notifications" and set it to disabled. That should keep the notifications from popping up when you're not actually running Chrome.
• Smooth Scrolling: If you're not getting smooth scrolling on Windows or Linux, turning this feature on should get smooth scrolling working properly.

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These are just a few we've tested and enjoyed. For the most part, you can fiddle around with the Chrome flags to your hearts content. Just make a note of what you're enabling (or disabling) so you can fix it in the future. Not every setting is going to work for everyone, and a few that sounded great, like "Enable desktop guest mode" and "Full History Sync" didn't work for us at all, but you might be able to get them running.

Photo by MARCELODLT and Evgeny Atamanenko.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/aBfe1gXS4cA/the-best-experimental-chrome-features-you-should-check-478620752

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Democrats Argue Over Who's Tougher on National Security After Boston Bombings

The last time terrorists struck while Massachusetts Democrat Stephen Lynch was campaigning for office, on Sept. 11, 2001, he coasted.

He easily won the Democratic primary that day and clinched a seat in Congress with a gauzy television ad in the general election that intoned, "At a time like this, we're not Democrats or Republicans. We're Americans."?

This time, when bombs exploded at the Boston Marathon in the homestretch of Lynch?s underdog campaign for the U.S Senate, he pounced.

After a week?s hiatus from the campaign trail, Lynch assailed his Democratic rival, Rep. Edward Markey, in a televised debate Monday for voting against the creation of an anti-terrorism task force in 2002. The unexpected attack -- expected to be replayed in the second and final debate of the primary Tuesday night -- is shaking up the quiet special election to replace now-Secretary of State John Kerry and could help Lynch close a double-digit gap in the polls by Tuesday?s vote.

?Clearly, the terrorist attack has given Lynch new purpose and energy in his campaign, which until this time had been flat,? said Boston-based Republican strategist Rob Gray, who is not involved in the race. ?Anything can happen in a low-turnout special-election primary, especially given the focus on the marathon bombings, though I still think Markey is the favorite.?

Lynch?s campaign faces a challenge familiar to politicians who have campaigned in the chaotic aftermath of natural disasters and acts of violence: how to draw the attention of a shell-shocked electorate without appearing to be exploiting a tragedy for political gain. What?s less customary is that the soft-on-terrorism line of attack is usually wielded by hawkish Republicans against more liberal Democrats. In this Democratic primary, bright lines already separate the more liberal Markey and more conservative Lynch on abortion rights, President Obama?s health care law and the Keystone XL Pipeline.

?I was waiting for the terrorism card to be played in the general election and didn?t expect this sort of intraparty maneuver on the part of Rep. Lynch,? said Tim Vercellotti, a political science professor at Western New England University, which found Lynch trailing Markey by 10 percentage points in a mid-April survey.

The more familiar political backbiting over the government?s response to terrorism was last seen in the 2010 Massachusetts Senate race, when Republican Scott Brown accused Democrat Martha Coakley of being na?ve about terrorist threats. Raising the issue of homeland security in next week?s Democratic primary could motivate independent voters who are eligible to participate and lean toward the more conservative Lynch.

?The news cycle is still absolutely dominated by coverage of the investigation, so for folks like Steve Lynch it?s really hard to get some traction,? Vercellotti added.? ?If he were to put an ad on the air he?d be playing with fire because he runs the risk of politicizing an event that?s still really raw, but emotions are high and it could resonate. It?s tricky.?

Markey?s campaign is vigorously defending his record on national security, pointing to his legislation to require better screening of airport cargo, opposition to allowing small knives on planes and advocacy for increased security at nuclear power plants. Only 33 Democrats voted for the anti-terrorism task force in 2002 because of concerns about U.S. military involvement in local law enforcement issues, said Markey spokesman Andrew Zucker.

?Steven Lynch?s personal attack on Markey?s national leadership on stopping terrorism and keeping Americans safe is a clear sign of desperation from a candidate with nowhere left to turn,? he said.

The Lynch campaign disagreed. ??We just spent a weekend watching the interaction between local and federal agencies, so talking about the candidates? differences on that policy is very relevant,? said Lynch?s spokesman, Scott Ferson. ?I guess we could have had another debate over the health care law, but now we are having a very different debate.?

The issue is also creeping into the Republican primary, which pits businessman Gabriel Gomez against former U.S. Attorney Michael Sullivan and State Rep. Dan Winslow. Gomez, a former Navy SEAL, has said he was ?disappointed? the federal government won?t be holding the surviving bomber suspect as an enemy combatant. Sullivan has called for revoking his citizenship.

"The bombing has completely transformed the race and brought national security and homeland defense to the forefront,? said Republican strategist Eric Fehrnstrom, who is working for a pro-Gomez super PAC. ?I think it will increase participation in the special election because you will see more independents turn out. People are playing closer attention now and they are going to be scrutinizing the candidates? records on homeland security and national defense issues.?

Source: http://news.yahoo.com/democrats-argue-over-whos-tougher-national-security-boston-151332538--politics.html

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TokBox Brings WebRTC To The Cloud, Enables Multi-Party Video Chats & SIP Interop

Telefonica’s TokBox announced a huge upgrade to its OpenTok on WebRTC service today. TokBox’s new cloud-based Mantis media distribution framework is designed to overcome some of WebRTC’s limits with regard to video distribution. By default, WebRTC is a peer-to-peer platform, but that makes it hard to scale video chats beyond two participants. With Mantis, TokBox essentially puts its own cloud infrastructure in the middle of these calls and is then able to route and manage calls that include multiple participants without using a prohibitive amount of bandwidth and using a complicated mesh-based architecture. In the future, as TokBox CEO Ian Small told me earlier this week, this will also enable TokBox to shape video streams according to the different users’ bandwidth conditions and the developers’ needs. “With Mantis, what we’re doing is putting smarts into the WebRTC infrastructure,” Small said. “Today, we’re routing traffic. Tomorrow, we’ll shape traffic.” On cool feature Mantis already enables today is SIP interop, so developers will actually be able to write WebRTC-based apps that allow users to call in from their standard phone lines. This, for example, is useful for video conferencing services where you can now have a number of WebRTC-based video streams and a few participants on regular phone lines simultaneously. Currently, Small told me, the system scales well for chats with up to 10 users. In a webinar setting where just one user is broadcasting, it can easily scale up to more than a hundred users. The company beta-tested Mantis with the help of LiveNinja and Roll20. Current OpenTok developers won’t have to do anything to take advantage of the new system, given that TokBox already abstracts most of the WebRTC calls anyway. They will just have to create the topology they need for their apps (P2P, multi-party chat, etc.) and get started. It just “happens in the cloud automatically,” as Small noted, and now that it’s in the cloud, the company will be able to add many new features to its implementation in the near future. WebRTC, of course, is still in its early phases, something Small also acknowledged in our interview. In his view, we are not even in the early adopter phase right now. Instead, he believes, WebRTC is still in its experimentation and early mover phase. Once WebRTC arrives in the stable release channel of Firefox (it’s about to hit the developer channels soon and should be in

Source: http://feedproxy.google.com/~r/Techcrunch/~3/wTQ9fSe290c/

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Virgin Media outlines Galaxy S 4 pricing, starts at ?31 per month with ?99 down

We've seen a few UK carriers show their cards ahead of the Galaxy S 4 launch this weekend, but MVNO Virgin Media has been slightly coy with details compared to bigger peers like EE and Vodafone. Better late than never, we suppose: the provider has outlined just how much we'll have to spend to get Samsung's flagship. Customers who have Virgin broadband or TV services can pay the same £31 per month as their EE counterparts, getting a lower £99 device cost and insurance in exchange for a more limited service that includes 200 minutes, 500 texts and 500MB of data. When mobile-only customers have to pay £5 more per month, though, we'd think carefully about signing up just for the sake of the GS 4. There are better deals afoot if you're not already a loyal Virgin customer.

Filed under: Cellphones, Mobile, Samsung

Comments

Source: Virgin Media

Source: http://www.engadget.com/2013/04/24/virgin-media-outlines-its-galaxy-s-4-pricing/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Children routinely injured or killed by guns, U.S. study shows; Access to loaded, unlocked firearms remains a problem

Apr. 23, 2013 ? While gun control issues usually surface after major incidents like the fatal shooting of 20 elementary school students in Newtown, Conn., a new study shows that children are routinely killed or injured by firearms.

The study, conducted by the Colorado School of Public Health, Denver Health and Children's Hospital Colorado, was published today in the Journal of the American Medical Association (JAMA). It examines trauma admissions at two emergency rooms in Denver and Aurora over nine years and found that 129 of 6,920 injured children suffered gunshot wounds.

"In 14 percent of these cases children managed to get access to unlocked, loaded guns," said the study's lead author Angela Sauaia, M.D., Ph.D., at the Colorado School of Public Health and the University of Colorado School of Medicine. "In an area with so much disagreement, I think we can all agree that children should not have unsupervised access to unlocked, loaded guns."

The study shows that at least 14 children between the ages four and 17 are injured by firearms every year in the Denver metro area alone. That number excludes those found dead at the scene. It also doesn't count those who did not go to the emergency department, so Sauaia believes the injury rates exceed 14 or roughly 2 percent of all child trauma admissions.

The number of gun injuries to children has changed little over the years.

According to state data, Colorado firearm death rates for children were 2.2 per 100,000 in the year 2000, 1.9 per 100,000 in 2009 and 2.8 per 100,000 in 2011.

"People tend to only pay attention to gun safety issues after these mass killings but this is happening all the time to our children and it's totally preventable," Sauaia said. "Are we as a society willing to accept that 14 or more children shot each year is an acceptable number?"

Sauaia, an associate professor of public health, medicine and surgery, studied child trauma admissions from 2000-2008 at Children's Hospital Colorado and Denver Health Medical Center. She found those who had been shot suffered significantly more severe wounds than children hurt with other objects and that the severity of the firearm injuries is increasing.

At the same time, 50 percent of shooting victims required intensive care. And, 13 percent died compared to 1.7 percent of children hurt in non-firearm incidents. The majority of those shot were adolescent males whose injuries were often self-inflicted.

Sauaia did not include the 1999 shootings at Columbine High School, which killed 12 students and injured another 21, in her study. The 2012 Aurora theater shootings, which killed 12 and wounded 58 last year, were also not in the time frame included in the study.

"When we examined the data we found that seven percent of the injuries to children were related to violence and of those 38 percent were related to guns," she said. "If the injury was gun related, the odds of dying were 10 times greater than from any other kind of injury."

Sauaia and her colleagues had done another study in 1993 that found that 42 percent of people who died from trauma incidents in Denver were killed by guns. That compared to 26 percent killed in car accidents.

She conducted both studies entirely without federal funding.

"There is little money to do gun research, which is unfortunate," Sauaia said. "But the point we can all agree upon is that, no matter what side of the gun divide you fall on, we need to store these weapons safely to protect our children from death or serious injury."

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Story Source:

The above story is reprinted from materials provided by University of Colorado Denver, via EurekAlert!, a service of AAAS. The original article was written by David Kelly.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Angela Sauaia, Joshua I. Miller, Ernest E. Moore, David Partrick. Firearm Injuries of Children and Adolescents in 2 Colorado Trauma Centers: 2000-2008. JAMA, 2013 DOI: 10.1001/jama.2013.3354

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/KwaTdY2X4os/130423161907.htm

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Cruise Holidays sets sail for new programs and marketing materials ...

Cruise Holidays ? the world?s most far-reaching cruise franchise network ? showed off a new look for its consumer-facing marketing materials, updated franchise owners on the success of their recent Facebook sweepstakes, and rolled out or announced the expansion of several programs designed to attract and retain clients, all during Cruise Holidays? 2013 Mid-Year Meeting, held on April 12-14, 2013.

Updated Website & Marketing Materials
Cruise Holidays? website, http://www.cruiseholidays.com, is receiving a makeover, along with the franchise network?s consumer-facing email communications and printed brochures. Cruise Holidays is adding new written content areas ? including professionally-written cruise reviews ? designed to attract and retain site visitors? attention. Printed brochures that Cruise Holidays sends to clients on behalf of franchise owners will also evolve to better attract clients? attention.

Facebook Sweepstakes
Cruise Holidays continues to train a base of franchise owners with diverse skill sets on Facebook marketing techniques, and recently wrapped up its second franchise-wide Facebook sweepstakes. This March, more than 40 franchise owners participated in the sweepstakes, giving consumers the chance to win a free AmaWaterways European river cruise for two. The sweepstakes was available via desktop as well as through mobile devices ? important because daily usage of Facebook via mobile now exceeds desktop usage.

Cruise Holidays provided comprehensive training for the participating franchise owners, including how to install the sweepstakes app on each of their pages, a complete graphics package and one-on-one coaching throughout the month so franchise owners could maximize their marketing efforts. More than 20,000 people registered for the sweepstakes, with 97% of those entries coming from Facebook.

Cruise Holidays Hosted Cruise Program & Cruise Holidays Cruise Values
On the operations front, Cruise Holidays unveiled a new hosted cruise program that provides its clients with three distinct advantages. Each sailing comes with the services of a concierge host, a private cocktail reception and an exclusive shore event at no additional cost. Cruise Holidays is currently partnering with eight cruise lines in this new program: two contemporary, and three premium and three luxury cruise lines.

?At the heart of it, we are a cruise franchise network, and that remains our core business,? said Tom Baumann , President of Travel Leaders Leisure Group, which Cruise Holidays is a part of. ?But to increase our competitive edge, we are increasing our portfolio of programs that more easily enable our cruise experts to serve as full-service, end-to-end travel professionals. The programs we?re providing are turnkey, allowing them to spend less time researching and more time selling,? added Baumann.

Recommended

Source: http://www.breakingtravelnews.com/news/article/cruise-holidays-sets-sail-for-new-programs-and-marketing-materials/

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For Cats, Especially Older Cats, Weight Loss May Not Be So Good ...

By Steve Dale, Monday at 2:22 pm

Weight loss sounds like a good thing, but not necessarily if the weight loss happens to be in a senior cat, as explained by feline veterinarian, Dr. Susan Little, past president of the Winn Feline Foundation.

Type your email address in the box and click the "create subscription" button. My list is completely spam free, and you can opt out at any time.

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Filed under: cats, veterinary health

Tags: cat health, Dr. Susan Little, DVM360, feline veterinarian, older cats, senior cats, Steve Dale, Steve Dale archives, weight loss cats, Winn Feline Foundation

Source: http://www.chicagonow.com/steve-dales-pet-world/2013/04/for-cats-especially-older-cats-weight-loss-may-not-be-so-good/

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Experimental therapy saves child born 'without bones'

Apr. 22, 2013 ? Four years ago, Janelly Martinez-Amador was confined to a bed, unable to move even an arm or lift her head. At age 3, the fragile toddler had the gross motor skills of a newborn and a ventilator kept her alive.

She was born with thin, fragile bones, and by 3, she had no visible bones on X-rays. Initially, doctors weren't sure she would survive her first birthday. In May, Janelly will turn 7, and is developing bone with the help of an experimental drug therapy and her care team at the Monroe Carell Jr. Children's Hospital at Vanderbilt.

Janelly has a rare genetic disorder called hypophosphatasia (HPP), a metabolic disease that affects the development of bone and teeth. An enzyme deficiency causes the bones to become soft because they can't absorb important minerals such as calcium and phosphorus, increasing the risks for pain, broken bones and bone deterioration.

"Imagine your child laying all the time in bed, not being able to lift herself, not being able to move herself, making sure she is not falling or tripping on things," her father, Salvadore Martinez, said through a Spanish interpreter.

"The treatment has worked very well but it has been a compilation of doctors, nurses, assistants ? everyone that has been a part of her care that has helped her make a meaningful recovery."

HPP affects about one in 100,000 babies born in the United States. While there are varying degrees of severity, the most severe forms of HPP occur before birth and early infancy. More than half of babies born with the disease don't survive beyond their first birthday. Janelly has the more severe form of the disease, which was diagnosed when she was 3 months old after failing to grow and gain weight. Doctors initially thought she might have cancer. With a thorough blood analysis at Children's Hospital, they diagnosed her with HPP.

"If you saw her in 2009 and see her now, it's not the same Janelly," said her mother, Janet Amador. "She used a ventilator, an oxygen mask -- many machines to help her breathe."

Janelly is one of 11 children, age 3 years and younger, to participate in a clinical trial to receive an enzyme-replacement drug therapy, asfotase alfa, for the life-threatening form of HPP. She had the worst case of the group.

Michael Whyte, M.D., the lead investigator of the study, which published results in March, 2012, in the New England Journal of Medicine, visited Janelly and her family at Children's Hospital last week. It was the first time he had met the family and her physician, Jill Simmons, M.D., a pediatric endocrinologist at Vanderbilt.

"It's wonderful that you had the faith that a treatment might come along. For many years, it seemed there was nothing that was very helpful for this disorder," said Whyte, medical-science director of the Center for Metabolic Bone Disease and Molecular Research at Shriner Hospitals for Children in St. Louis.

"We were fearful that her bone disease was so terribly severe that it might not work. But by looking at the X-rays and hearing about her visits, we were thrilled to hear about her progress."

About eight months into the treatment, Janelly's parents felt her fingers -- which had been completely soft and boneless -- and they could feel traces of developing bone. Her head also began to develop bone. At 18 months into therapy, X-rays showed, for the first time, the visible development of her rib cage.

Janelly now sits in a wheelchair. Recently, dressed in her Easter best and bright pink bows, she was able to turn her head to gaze at a room of onlookers.

She smiled and waved her hand excitedly, a feat she never would have accomplished before the drug therapy. She is also able to attend school at Harris-Hillman Special Education School, not far from Children's Hospital.

This spring, doctors hope to be able to remove her tracheostomy tube, which has prevented her from speaking. Her developmental and cognitive abilities will be tested in July. Improvement continues each day, each week for Janelly.

"This is why we get into medicine in the first place: to truly make a difference in the life of a child," said Simmons, her physician. "My goodness, to go from no bones to bones. That's the most impressive thing I have seen as a physician. It's incredible."

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The above story is reprinted from materials provided by Vanderbilt University Medical Center, via Newswise.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/iOUoTh1m38E/130422111107.htm

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